The bla_SHV genes (sulfhydryl-variable β-lactamases) are a family of plasmid-mediated β-lactamases, originally from Klebsiella, that include many extended-spectrum variants (ESBLs). SHV-type ESBLs hydrolyze oxyimino-cephalosporins (e.g. cefotaxime, ceftazidime) and monobactams; they are typically co-transferred with other resistance genes. Detecting bla_SHV in a clinical isolate suggests an ESBL-mediated resistance phenotype, to provide correct antibiotic treatment (Tzouvelekis et al. 2012, Liakopoulos et al. 2016).
Liakopoulos, A., Mevius, D., & Ceccarelli, D. (2016). A Review of SHV Extended-Spectrum β-Lactamases: Neglected Yet Ubiquitous. Frontiers in microbiology, 7, 1374. https://doi.org/10.3389/fmicb.2016.01374
Tzouvelekis, L. S., Markogiannakis, A., Psichogiou, M., Tassios, P. T., & Daikos, G. L. (2012). Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clinical Microbiology Reviews, 25(4), 682–707.
