bla_VIM

bla_VIM is a class B metallo-β-lactamase gene that confers high-level resistance to carbapenems and most β-lactams (via broad-spectrum hydrolysis) in Gram-negative bacteria like Pseudomonas aeruginosa and Enterobacteriaceae. Detection of bla_VIM signals a highly resistant organism (often hospital‐acquired) that will not respond to carbapenems; its presence typically prompts use of last-line agents and strict infection control measures (Vega et al. 2024, Nordmann et al. 2012).

References:
Nordmann, P., Poirel, L., & Dortet, L. (2012). Rapid detection of carbapenemase-producing Enterobacteriaceae. Emerging infectious diseases, 18(9), 1503–1507. https://doi.org/10.3201/eid1809.120355

Vega, A. D., DeRonde, K., Jimenez, A., Piazza, M., Vu, C., Martinez, O., Rojas, L. J., Marshall, S., Yasmin, M., Bonomo, R. A., & Abbo, L. M. (2024). Difficult-to-treat (DTR) Pseudomonas aeruginosa harboring Verona-Integron metallo-β-lactamase (bla_VIM): infection management and molecular analysis. Antimicrobial agents and chemotherapy, 68(5), e0147423. https://doi.org/10.1128/aac.01474-23