Candida glabrata is a non-albicans Candida species associated with urinary tract infections and wound infections.
Urinary tract infections: Candida glabrata is an emerging non-albicans Candida species increasingly associated with UTIs, especially in older adults and those with diabetes or recent antifungal exposure. It is less susceptible to fluconazole compared to C. albicans, which can impact treatment decisions. Molecular detection is important due to its slower growth in culture and rising prevalence in nosocomial infections (Pfaller & Diekema 2007, Silva et al. 2012).
Wound infections: Candida glabrata is a common non-albicans Candida species associated with chronic wound infections, often displaying reduced susceptibility to azole antifungals. Its ability to persist in biofilms complicates eradication and prolongs infection. Early detection of C. glabrata informs antifungal selection and improves wound care strategies (Hassan et al. 2021, Silva et al. 2012)
Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007 Jan;20(1):133-63. doi: 10.1128/CMR.00029-06. PMID: 17223626; PMCID: PMC1797637.
Silva S, Negri M, Henriques M, Oliveira R, Williams DW, Azeredo J. Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiol Rev. 2012 Mar;36(2):288-305.
Hassan, Y., Chew, S. Y., & Than, L. T. L. (2021). Candida glabrata: Pathogenicity and Resistance Mechanisms for Adaptation and Survival. Journal of fungi (Basel, Switzerland), 7(8), 667.
