HCoV-229E is a common cold coronavirus that usually causes mild upper respiratory illness, but can occasionally cause bronchitis or pneumonia in infants, the elderly, and immunocompromised patients. Its inclusion is justified by its role in seasonal respiratory disease and its potential severity in vulnerable hosts (Gaunt et al. 2010, Jo et al. 2022).
References:
Gaunt, E. R., Hardie, A., Claas, E. C., Simmonds, P., & Templeton, K. E. (2010). Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method. Journal of clinical microbiology, 48(8), 2940–2947. https://doi.org/10.1128/JCM.00636-10
Jo, K. J., Choi, S. H., Oh, C. E., Kim, H., Choi, B. S., Jo, D. S., & Park, S. E. (2022). Epidemiology and Clinical Characteristics of Human Coronaviruses-Associated Infections in Children: A Multi-Center Study. Frontiers in pediatrics, 10, 877759. https://doi.org/10.3389/fped.2022.877759
