Globicatella sanguinis is a rare, catalase-negative, gram-positive coccus often mistaken for viridans streptococci. It has been reported as a pathogen in infections of the urine, bloodstream, and central nervous system, especially in elderly women. G. sanguinis can cause severe UTIs that complicate to bacteremia or endocarditis. Including G. sanguinis in a UTI PCR panel ensures these uncommon infections are detected (Miller et al. 2017, Moreland et al. 2023).
Moreland RB, Choi BI, Geaman W, Gonzalez C, Hochstedler-Kramer BR, John J, Kaindl J, Kesav N, Lamichhane J, Lucio L, Saxena M, Sharma A, Tinawi L, Vanek ME, Putonti C, Brubaker L, Wolfe AJ. 2023. Beyond the usual suspects: emerging uropathogens in the microbiome age. Front Urol 3:1212590
Miller, A. O., Buckwalter, S. P., Henry, M. W., Wu, F., Maloney, K. F., Abraham, B. K., Hartman, B. J., Brause, B. D., Whittier, S., Walsh, T. J., & Schuetz, A. N. (2017). Globicatella sanguinis Osteomyelitis and Bacteremia: Review of an Emerging Human Pathogen with an Expanding Spectrum of Disease. Open forum infectious diseases, 4(1), ofw277. https://doi.org/10.1093/ofid/ofw277
