IMP-7

IMP-7 Overview

IMP-7 is a class B metallo-β-lactamase variant originally identified in a nosocomial Pseudomonas aeruginosa outbreak. It hydrolyzes carbapenems similarly to other IMP enzymes, and has since been found globally). Including IMP-7 in the panel captures this specific MBL that can cause otherwise unexplained carbapenem resistance (Logan & Weinstein 2017, Nordmann et al. 2012).

 

References:

Logan, L. K., & Weinstein, R. A. (2017). The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace. The Journal of Infectious Diseases, 215(suppl_1), S28–S36.

Nordmann, P., Poirel, L., & Dortet, L. (2012). Rapid Detection of Carbapenemase-Producing Enterobacteriaceae. Emerging Infectious Diseases, 18(9), 1503–1507.

Products used to detect IMP-7

The antibiotic resistance marker large PCR panel is designed for multiplex in vitro assessment of 21 common antibiotic resistant genes, using real-time PCR.