Influenza A viruses are a major inclusion in respiratory panels because seasonal epidemics and occasional pandemics, leading to millions of US cases each year, hundreds of thousands of hospitalizations, and tens of thousands of deaths. Early detection is essential because influenza A is treatable with antivirals and its presence impacts infection control and vaccination strategies (Uyeki et al. 2018, Cozza et al. 2021).
Uyeki, T. M., Bernstein, H. H., Bradley, J. S., Englund, J. A., File, T. M., Fry, A. M., Gravenstein, S., Hayden, F. G., Harper, S. A., Hirshon, J. M., Ison, M. G., Johnston, B. L., Knight, S. L., McGeer, A., Riley, L. E., Wolfe, C. R., Alexander, P. E., & Pavia, A. T. (2019). Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 68(6), e1–e47. https://doi.org/10.1093/cid/ciy866
Cozza, V., Campbell, H., Chang, H. H., Iuliano, A. D., Paget, J., Patel, N. N., Reiner, R. C., Troeger, C., Viboud, C., Bresee, J. S., & Fitzner, J. (2021). Global Seasonal Influenza Mortality Estimates: A Comparison of 3 Different Approaches. American journal of epidemiology, 190(5), 718–727. https://doi.org/10.1093/aje/kwaa196