Klebsiella aerogenes (formerly Enterobacter aerogenes) is a gram-negative rod implicated in urinary tract infections and wound infections.
Urinary tract infections: Klebsiella aerogenes is implicated in hospital-acquired UTIs, particularly among patients with indwelling catheters or compromised immune systems. It is known for rapid acquisition of multidrug resistance, including extended-spectrum β-lactamases (ESBL) and carbapenemase production. Its ability to colonize the urinary tract and cause ascending infections supports its inclusion in comprehensive PCR diagnostics (Davin-Regli & Pagès 2015, Davin-Regli et al. 2019, Intra et al. 2023)
Wound infections: Klebsiella aerogenes can cause wound and surgical site infections, especially in nosocomial settings. It is part of the ESKAPE group and exhibits notable resistance to antibiotics, particularly due to AmpC beta-lactamase production. K. aerogenes has been implicated in infections in burns and open wounds, requiring careful antimicrobial stewardship (Davin-Regli & Pagès 2015, Tamma et al. 2019)
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Davin-Regli A, Lavigne JP, Pagès JM. Enterobacter spp.: Update on Taxonomy, Clinical Aspects, and Emerging Antimicrobial Resistance. Clin Microbiol Rev. 2019 Jul 17;32(4):e00002-19. doi: 10.1128/CMR.00002-19. PMID: 31315895; PMCID: PMC6750132.
Intra, J., Carcione, D., Sala, R. M., Siracusa, C., Brambilla, P., & Leoni, V. (2023). Antimicrobial Resistance Patterns of Enterobacter cloacae and Klebsiella aerogenes Strains Isolated from Clinical Specimens: A Twenty-Year Surveillance Study. Antibiotics (Basel, Switzerland), 12(4), 775.
Tamma, P. D., Doi, Y., Bonomo, R. A., Johnson, J. K., Simner, P. J., & Antibacterial Resistance Leadership Group (2019). A Primer on AmpC β-Lactamases: Necessary Knowledge for an Increasingly Multidrug-resistant World. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 69(8), 1446–1455.
