Pseudomonas aeruginosa is a gram-negative bacterium associated with urinary tract infections and wound infections.
Urinary tract infections: Pseudomonas aeruginosa is a highly adaptable gram-negative bacterium that causes complicated UTIs, especially in immunocompromised patients or those with urinary catheters. It is notorious for antibiotic resistance and for forming biofilms on urinary devices, leading to chronic infections. Its relevance in hospital-acquired UTIs and need for targeted therapy make its detection via molecular methods essential (Mittal et al. 2009, Timm et al. 2025).
Wound infections: Pseudomonas aeruginosa is one of the most common and challenging pathogens in wound care due to its multidrug resistance and biofilm-forming ability. It frequently infects burn wounds and chronic ulcers, causing delayed healing and increased morbidity. P. aeruginosa thrives in moist environments and produces toxins that damage tissue. Prompt identification enables initiation of antipseudomonal therapy and mitigates risk of dissemination (Azzopardi et al. 2014).
Mittal R, Aggarwal S, Sharma S, Chhibber S, Harjai K. Urinary tract infections caused by Pseudomonas aeruginosa: a minireview. J Infect Public Health. 2009;2(3):101-11. doi: 10.1016/j.jiph.2009.08.003. Epub 2009 Sep 19. PMID: 20701869.
Timm, M.R., Russell, S.K. & Hultgren, S.J. Timm, M.R., Russell, S.K. & Hultgren, S.J. Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics. Nat Rev Microbiol 23, 72–86 (2025).
Azzopardi, E. A., Azzopardi, E., Camilleri, L., Villapalos, J., Boyce, D. E., Dziewulski, P., Dickson, W. A., & Whitaker, I. S. (2014). Gram negative wound infection in hospitalised adult burn patients–systematic review and metanalysis-. PloS one, 9(4), e95042.
