Staphylococcus saprophyticus is not only associated with urinary tract infections but also wound infections.
Urinary tract infections: Staphylococcus saprophyticus is a leading cause of uncomplicated UTIs in young, sexually active women, second only to E. coli. It adheres strongly to uroepithelial cells and can persist in the urinary tract without significant symptoms, sometimes leading to delayed diagnosis. Given its frequency in this demographic and its resistance to certain antibiotics, it is a crucial component of targeted molecular testing (Zhang et al. 2023, Flores et al. 2015).
Wound infections: Staphylococcus saprophyticus is primarily associated with urinary tract infections but has been identified in wound infections, particularly in immunocompromised individuals. It is coagulase-negative and may be overlooked in polymicrobial cultures. S. saprophyticus can cause wound infections following trauma or surgery and may demonstrate resistance to common antibiotics (Zhang et al. 2023).
Zhang K, Potter RF, Marino J, Muenks CE, Lammers MG, Dien Bard J, Dingle TC, Humphries R, Westblade LF, Burnham C-AD, Dantas G. Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of Staphylococcus saprophyticus. mSystems. 2023 Dec 21;8(6):e0069723. doi: 10.1128/msystems.00697-23. Epub 2023 Dec 5. PMID: 38051037; PMCID: PMC10734486.
Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015 May;13(5):269-284.
Raz R, Colodner R, Kunin CM. Who are you–Staphylococcus saprophyticus? Clin Infect Dis. 2005 Mar 15;40(6):896-8. doi: 10.1086/428353. Epub 2005 Feb 16. PMID: 15736028.
